PDBsum entry 3cxx

Oxidoreductase

PDB id: 3cxx

Contents

Protein chain

395 a.a. *

Ligands

SO4 ×3

HEM

Waters ×442

* Residue conservation analysis

PDB id:

3cxx

Name:

Oxidoreductase

Title:

Crystal structure of cytochrome p450 cyp121 f338h from m. Tuberculosis

Structure:

Cytochrome p450 121. Chain: a. Synonym: p450 mt2. Engineered: yes. Mutation: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: cyp121. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å R-factor: 0.176 R-free: 0.217

Authors:

D.Leys

Key ref:

K.J.Mclean et al. Characterization of the active site structure of cy121. To be published, .

Date:

25-Apr-08 Release date: 23-Sep-08

Protein chain

P9WPP7  (CP121_MYCTU) -  Mycocyclosin synthase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 396 a.a.

Struc: 395 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.1.14.19.70 - mycocyclosin synthase.
• Reaction: cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H⁺ = mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O
• Cofactor: Heme-thiolate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site