PDBsum entry 3c0c

Endocytosis

PDB id

3c0c

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Contents

			Protein chain

					64 a.a. *

			Waters ×83

* Residue conservation analysis

PDB id:

3c0c

Links

Name:

Endocytosis

Title:

X-ray crystal structure of the rat endophilin a2 sh3 domain

Structure:

Endophilin-a2. Chain: a. Fragment: sh3 domain. Synonym: endophilin-2, sh3 domain-containing grb2-like protein 1, sh3 domain protein 2b, extra eleven-nineteen leukemia fusion gene protein, een, een fusion partner of mll. Engineered: yes

Source:

Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: sh3gl1, sh3p8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.70Å

R-factor:

0.197

R-free:

0.217

Authors:

P.J.Loll,E.Swain

Key ref:

P.J.Loll et al. (2008). Structure of the SH3 domain of rat endophilin A2. Acta Crystallogr Sect F Struct Biol Cryst Commun, 64, 243-246. PubMed id: 18391417

Date:

19-Jan-08

Release date:

18-Mar-08

PROCHECK

	Headers

	References

Protein chain

O35964 (SH3G1_RAT) - Endophilin-A2 from Rattus norvegicus

Seq: Struc:					368 a.a. 64 a.a.

Key:

Secondary structure

CATH domain

	Acta Crystallogr Sect F Struct Biol Cryst Commun 64:243-246 (2008)
PubMed id: 18391417

Structure of the SH3 domain of rat endophilin A2.
P.J.Loll, E.Swain, Y.Chen, B.T.Turner, J.F.Zhang.

ABSTRACT

The crystal structure of the SH3 domain of rat endophilin A2 has been determined by the multiwavelength anomalous dispersion method and refined at a resolution of 1.70 A to R and R(free) values of 0.196 and 0.217, respectively. The structure adheres to the canonical SH3-domain fold and is highly similar to those of the corresponding domains of endophilins A1 and A3. An intermolecular packing interaction between two molecules in the lattice exploits features that are commonly observed in SH3-domain ligand recognition, including the insertion of a proline side chain into the ligand-binding groove of the protein and the recognition of a basic residue by a cluster of acidic side chains on the RT loop.

Literature references that cite this PDB file's key reference

PubMed id

Reference

19406745

R.Goetz, K.Dover, F.Laezza, N.Shtraizent, X.Huang, D.Tchetchik, A.V.Eliseenkova, C.F.Xu, T.A.Neubert, D.M.Ornitz, M.Goldfarb, and M.Mohammadi (2009).
Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.

J Biol Chem, 284, 17883-17896.

PDB code:

3hbw

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