PDBsum entry 3c0c

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protein links
Endocytosis PDB id
Protein chain
64 a.a. *
Waters ×83
* Residue conservation analysis
PDB id:
Name: Endocytosis
Title: X-ray crystal structure of the rat endophilin a2 sh3 domain
Structure: Endophilin-a2. Chain: a. Fragment: sh3 domain. Synonym: endophilin-2, sh3 domain-containing grb2-like prot domain protein 2b, extra eleven-nineteen leukemia fusion ge protein, een, een fusion partner of mll. Engineered: yes
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: sh3gl1, sh3p8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
1.70Å     R-factor:   0.197     R-free:   0.217
Authors: P.J.Loll,E.Swain
Key ref: P.J.Loll et al. (2008). Structure of the SH3 domain of rat endophilin A2. Acta Crystallogr Sect F Struct Biol Cryst Commun, 64, 243-246. PubMed id: 18391417
19-Jan-08     Release date:   18-Mar-08    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
O35964  (SH3G1_RAT) -  Endophilin-A2
368 a.a.
64 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     endocytosis   1 term 


Acta Crystallogr Sect F Struct Biol Cryst Commun 64:243-246 (2008)
PubMed id: 18391417  
Structure of the SH3 domain of rat endophilin A2.
P.J.Loll, E.Swain, Y.Chen, B.T.Turner, J.F.Zhang.
The crystal structure of the SH3 domain of rat endophilin A2 has been determined by the multiwavelength anomalous dispersion method and refined at a resolution of 1.70 A to R and R(free) values of 0.196 and 0.217, respectively. The structure adheres to the canonical SH3-domain fold and is highly similar to those of the corresponding domains of endophilins A1 and A3. An intermolecular packing interaction between two molecules in the lattice exploits features that are commonly observed in SH3-domain ligand recognition, including the insertion of a proline side chain into the ligand-binding groove of the protein and the recognition of a basic residue by a cluster of acidic side chains on the RT loop.

Literature references that cite this PDB file's key reference

  PubMed id Reference
19406745 R.Goetz, K.Dover, F.Laezza, N.Shtraizent, X.Huang, D.Tchetchik, A.V.Eliseenkova, C.F.Xu, T.A.Neubert, D.M.Ornitz, M.Goldfarb, and M.Mohammadi (2009).
Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.
  J Biol Chem, 284, 17883-17896.
PDB code: 3hbw
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