PDBsum entry: 3bx7

De novo protein, protein binding

PDB id: 3bx7

Contents

Protein chains

120 a.a. *

173 a.a. *

Waters ×186

* Residue conservation analysis

PDB id:

3bx7

Name:

De novo protein, protein binding

Title:

Engineered human lipocalin 2 (lcn2) in complex with the extracellular domain of human ctla-4

Structure:

Cytotoxic t-lymphocyte-associated antigen 4. Chain: c. Synonym: ctla-4, cd152, cytotoxic t-lymphocyte protein 4. Engineered: yes. Engineered human lipocalin 2. Chain: a. Synonym: engineered lcn2, engineered neutrophil-gelatinase associated lipocalin, engineered siderocalin. Engineered: yes

Source:

Homo sapiens. Human. Gene: ctla4, cd152. Expressed in: escherichia coli.

Resolution:

2.10Å R-factor: 0.209 R-free: 0.226

Authors:

D.L.Schonfeld,L.Chatwell,A.Skerra

Key ref:

D.L.Schonfeld et al. High affinity molecular recognition and functional blockade of ctla-4 by an engineered human lipocalin. To be published,

Date:

11-Jan-08 Release date: 20-Jan-09

Protein chain

P16410  (CTLA4_HUMAN) -  Cytotoxic T-lymphocyte protein 4

Seq: 223 a.a.

Struc: 120 a.a.

Protein chain

No UniProt id for this chain

 Gene Ontology (GO) functional annotation 

• Cellular component: membrane (1 term)
• Biological process: immune response (2 terms)
• Biochemical function: transporter activity (2 terms)