Protein tyrosine phosphatase ptpn-22 (lyp) bound to the mono-phosphorylated lck active site peptide
Tyrosine-protein phosphatase non-receptor type 22. Chain: a, b. Fragment: substrate trapped catalytic domain. Synonym: hematopoietic cell protein-tyrosine phosphatase 70z-pep, lymphoid phosphatase, lyp. Engineered: yes. Mutation: yes. Lck active site peptide.
Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn22, ptpn8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence of the peptide is naturally found in home
Lyp/ptpn22 phosphatase domain: substrate recognition and specificity for src family kinases.
To be published,