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PDBsum entry 3brh
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Protein tyrosine phosphatase ptpn-22 (lyp) bound to the mono- phosphorylated lck active site peptide
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Structure:
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Tyrosine-protein phosphatase non-receptor type 22. Chain: a, b. Fragment: substrate trapped catalytic domain. Synonym: hematopoietic cell protein-tyrosine phosphatase 70z-pep, lymphoid phosphatase,lyp,pest-domain phosphatase,pep. Engineered: yes. Mutation: yes. Lck active site peptide. Chain: c, d.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn22, ptpn8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence of the peptide is naturally found in home sapiens(human).
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Resolution:
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2.20Å
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R-factor:
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0.191
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R-free:
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0.264
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Authors:
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R.D.Seidel,J.Love,A.Piserchio,D.Cowburn
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Key ref:
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R.Seidel
et al.
Lyp/ptpn22 phosphatase domain: substrate recognition and specificity for src family kinases.
To be published,
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Date:
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21-Dec-07
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Release date:
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17-Feb-09
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PROCHECK
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Headers
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References
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Q9Y2R2
(PTN22_HUMAN) -
Tyrosine-protein phosphatase non-receptor type 22 from Homo sapiens
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Seq:
Struc:
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807 a.a.
296 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.3.1.3.48
- protein-tyrosine-phosphatase.
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Reaction:
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O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
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O-phospho-L-tyrosyl-[protein]
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+
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H2O
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=
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L-tyrosyl-[protein]
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+
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phosphate
Bound ligand (Het Group name = )
corresponds exactly
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
