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PDBsum entry 3bhg

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protein ligands links
Lyase PDB id
3bhg
Jmol
Contents
Protein chain
448 a.a. *
Ligands
SO4 ×2
GOL
Waters ×273
* Residue conservation analysis
PDB id:
3bhg
Name: Lyase
Title: Crystal structure of adenylosuccinate lyase from legionella pneumophila
Structure: Adenylosuccinate lyase. Chain: a. Engineered: yes
Source: Legionella pneumophila subsp. Pneumoph philadelphia 1. Organism_taxid: 272624. Strain: philadelphia 1, dsm 7513. Atcc: 33152. Gene: lpg0801. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.90Å     R-factor:   0.168     R-free:   0.195
Authors: C.Chang,H.Li,L.Freeman,A.Joachimiak,Midwest Center For Struc Genomics (Mcsg)
Key ref: C.Chang et al. Crystal structure of adenylosuccinate lyase from legionella pneumophila.. To be published, .
Date:
28-Nov-07     Release date:   04-Dec-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q5ZXD1  (PUR8_LEGPH) -  Adenylosuccinate lyase
Seq:
Struc:
456 a.a.
448 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.3.2.2  - Adenylosuccinate lyase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Purine Biosynthesis (late stages)
      Reaction:
1. N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP
2. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide
N(6)-(1,2-dicarboxyethyl)AMP
=
fumarate
Bound ligand (Het Group name = GOL)
matches with 40.00% similarity
+ AMP
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate
=
fumarate
Bound ligand (Het Group name = GOL)
matches with 40.00% similarity
+ 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     'de novo' AMP biosynthetic process   5 terms 
  Biochemical function     catalytic activity     4 terms