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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Crystal structure of mRNA cap guanine-n7 methyltransferase in complex with sah
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Structure:
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mRNA cap guanine-n7 methyltransferase. Chain: a, b, c, d. Fragment: residues 165-476. Synonym: mRNA (guanine-n(7)-)-methyltransferase, rg7mt1, mRNA cap methyltransferase, hcm1p, hcmt1, hmet. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: rnmt, kiaa0398. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.30Å
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R-factor:
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0.225
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R-free:
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0.294
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Authors:
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V.V.Lunin,H.Wu,H.Zeng,T.Antoshenko,F.Mackenzie,J.Weigelt, C.H.Arrowsmith,A.M.Edwards,A.Bochkarev,J.Min,A.N.Plotnikov, Structural Genomics Consortium (Sgc)
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Key ref:
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H.Wu
et al.
The crystal structure of human RNA (guanine-7-) Methyltransferase in complex with sah..
To be published,
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Date:
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27-Nov-07
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Release date:
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04-Dec-07
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PROCHECK
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Headers
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References
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O43148
(MCES_HUMAN) -
mRNA cap guanine-N7 methyltransferase
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Seq:
Struc:
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476 a.a.
269 a.a.
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Key: |
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PfamA domain |
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PfamB domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.56
- mRNA (guanine-N(7)-)-methyltransferase.
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Reaction:
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S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
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S-adenosyl-L-methionine
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+
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G(5')pppR-RNA
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=
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S-adenosyl-L-homocysteine
Bound ligand (Het Group name = )
corresponds exactly
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+
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m(7)G(5')pppR-RNA
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Gene Ontology (GO) functional annotation
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Biological process
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mRNA capping
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1 term
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Links
