PDBsum entry: 3baa

Ligase

PDB-id: 3baa

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Description

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Header records

References

PROCHECK

Protein chain

312 a.a. *

Ligands

SO4 ×4

NMN

3BA

GOL ×2

Waters ×269

* Residue conservation analysis

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PDB id:

3baa

Name:

Ligase

Title:

Structural basis for the inhibition of bacterial NAD+ dependent DNA ligase

Structure:

DNA ligase. Chain: a. Fragment: adenylation domain. Engineered: yes

Source:

Enterococcus faecalis. Streptococcus faecalis. Organism_taxid: 1351. Gene: liga. Expressed in: escherichia coli. Expression_system_taxid: 562

UniProt:

Q837V6 (Q837V6_ENTFA)

Seq:

Struc:

Seq:

Struc:

Seq:

676 a.a.

Struc:

312 a.a.

Key:

PfamA domain

Secondary structure

Enzyme class:

E.C.6.5.1.2   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Reaction:

NAD⁺ + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide + (deoxyribonucleotide)(n+m) (see diagram below)

Resolution:

1.90Å

R-factor:

0.187

R-free:

0.216

Authors:

C.Pinko

Key ref:

c.pinko et al. structural basis for the inhibition of bacterial nad+ dependent dna ligase. TO BE PUBLISHED, .

Date:

07-Nov-07

Release date:

11-Nov-08

Related entries:

3ba8
3ba9
3bab

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