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PDBsum entry 3alx

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protein ligands Protein-protein interface(s) links
Viral protein/membrane protein PDB id
3alx
Jmol
Contents
Protein chains
515 a.a.
Ligands
NAG ×6
PDB id:
3alx
Name: Viral protein/membrane protein
Title: Crystal structure of the measles virus hemagglutinin bound t cellular receptor slam (mv-h(l482r)-slam(n102h/r108y) fusio
Structure: Hemagglutinin, cdw150. Chain: a, b, c, d. Fragment: hemagglutinin head domain/cd150 v domain, unp rei 140. Synonym: cd150, signaling lymphocytic activation molecule 1 engineered: yes. Mutation: yes. Other_details: mv-h/slam fusion protein
Source: Measles virus, saguinus oedipus. Cotton-top tamarin. Organism_taxid: 11234,9490. Strain: edmonston b, b95a. Gene: hemagglutinin, cd150. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293sgnti(-).
Resolution:
3.15Å     R-factor:   0.231     R-free:   0.292
Authors: T.Hashiguchi,T.Ose,M.Kubota,N.Maita,J.Kamishikiryo,K.Maenaka
Key ref: T.Hashiguchi et al. (2011). Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM. Nat Struct Mol Biol, 18, 135-141. PubMed id: 21217702
Date:
09-Aug-10     Release date:   12-Jan-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P08362  (HEMA_MEASE) -  Hemagglutinin glycoprotein
Seq:
Struc:
 
Seq:
Struc:
617 a.a.
515 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 15 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell surface   3 terms 
  Biological process     viral infectious cycle   2 terms 
  Biochemical function     receptor activity     3 terms  

 

 
Nat Struct Mol Biol 18:135-141 (2011)
PubMed id: 21217702  
 
 
Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM.
T.Hashiguchi, T.Ose, M.Kubota, N.Maita, J.Kamishikiryo, K.Maenaka, Y.Yanagi.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23202587 X.Zhang, G.Lu, J.Qi, Y.Li, Y.He, X.Xu, J.Shi, C.W.Zhang, J.Yan, and G.F.Gao (2013).
Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4.
  Nat Struct Mol Biol, 20, 67-72.
PDB code: 4gjt
21289649 E.O.Saphire, and M.B.Oldstone (2011).
Measles virus fusion shifts into gear.
  Nat Struct Mol Biol, 18, 115-116.  
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