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PDBsum entry 3alq

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protein metals Protein-protein interface(s) links
Cytokine/cytokine receptor PDB id
3alq
Jmol
Contents
Protein chains
(+ 0 more) 141 a.a. *
(+ 0 more) 162 a.a. *
Metals
_CO ×6
Waters ×11
* Residue conservation analysis
PDB id:
3alq
Name: Cytokine/cytokine receptor
Title: Crystal structure of tnf-tnfr2 complex
Structure: Tumor necrosis factor. Chain: a, b, c, d, e, f. Fragment: soluble form. Synonym: tnf-alpha, tumor necrosis factor ligand superfamil 2, tnf-a, cachectin. Engineered: yes. Mutation: yes. Tumor necrosis factor receptor superfamily member chain: r, s, t, u, v, w.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnf, tnfa, tnfsf2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tnfbr, tnfr2, tnfrsf1b.
Resolution:
3.00Å     R-factor:   0.220     R-free:   0.281
Authors: Y.Mukai,T.Nakamura,Y.Yamagata,Y.Tsutsumi
Key ref: Y.Mukai et al. (2010). Solution of the structure of the TNF-TNFR2 complex. Sci Signal, 3, ra83. PubMed id: 21081755
Date:
06-Aug-10     Release date:   17-Nov-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01375  (TNFA_HUMAN) -  Tumor necrosis factor
Seq:
Struc:
233 a.a.
141 a.a.*
Protein chains
Pfam   ArchSchema ?
P20333  (TNR1B_HUMAN) -  Tumor necrosis factor receptor superfamily member 1B
Seq:
Struc:
461 a.a.
162 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 6 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   2 terms 
  Biological process     immune response   3 terms 
  Biochemical function     tumor necrosis factor receptor binding     1 term  

 

 
Sci Signal 3:ra83 (2010)
PubMed id: 21081755  
 
 
Solution of the structure of the TNF-TNFR2 complex.
Y.Mukai, T.Nakamura, M.Yoshikawa, Y.Yoshioka, S.Tsunoda, S.Nakagawa, Y.Yamagata, Y.Tsutsumi.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21512023 H.Wu, and R.M.Siegel (2011).
Medicine. Progranulin resolves inflammation.
  Science, 332, 427-428.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.