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PDBsum entry 3al8

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protein ligands Protein-protein interface(s) links
Signaling protein PDB id
3al8
Jmol
Contents
Protein chains
537 a.a. *
499 a.a. *
Ligands
NAG ×3
NAG-NAG ×2
NAG-NAG-BMA-MAN-
MAN-MAN-MAN
* Residue conservation analysis
PDB id:
3al8
Name: Signaling protein
Title: Plexin a2 / semaphorin 6a complex
Structure: Semaphorin-6a. Chain: a. Fragment: sema and psi domain (unp residues 19-570). Synonym: semaphorin via, sema via, semaphorin-6a-1, sema6a- semaphorin q, sema q. Engineered: yes. Plexin-a2. Chain: b. Fragment: sema and psi domain (unp residues 31-561).
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: sema6a, semaq. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: cho lec 3.2.8.1. Gene: plxna2, kiaa0463. Expressed in: homo sapiens.
Resolution:
3.60Å     R-factor:   0.233     R-free:   0.287
Authors: T.Nogi,N.Yasui,E.Mihara,J.Takagi
Key ref: T.Nogi et al. (2010). Structural basis for semaphorin signalling through the plexin receptor. Nature, 467, 1123-1127. PubMed id: 20881961
Date:
28-Jul-10     Release date:   06-Oct-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
O35464  (SEM6A_MOUSE) -  Semaphorin-6A
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1031 a.a.
537 a.a.
Protein chain
Pfam   ArchSchema ?
P70207  (PLXA2_MOUSE) -  Plexin-A2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1894 a.a.
499 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   1 term 
  Biological process     multicellular organismal development   1 term 
  Biochemical function     receptor activity     1 term  

 

 
Nature 467:1123-1127 (2010)
PubMed id: 20881961  
 
 
Structural basis for semaphorin signalling through the plexin receptor.
T.Nogi, N.Yasui, E.Mihara, Y.Matsunaga, M.Noda, N.Yamashita, T.Toyofuku, S.Uchiyama, Y.Goshima, A.Kumanogoh, J.Takagi.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23104057 B.J.Janssen, T.Malinauskas, G.A.Weir, M.Z.Cader, C.Siebold, and E.Y.Jones (2012).
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
  Nat Struct Mol Biol, 19, 1293-1299.
PDB codes: 4gz8 4gz9 4gza
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.