PDBsum entry 3al8

Signaling protein

PDB id

3al8

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Contents

			Protein chains

					537 a.a. *


					499 a.a. *

			Ligands

					NAG-NAG ×2


					NAG-NAG-BMA-MAN- MAN-MAN-MAN


					NAG ×3

* Residue conservation analysis

PDB id:

3al8

Links

Name:

Signaling protein

Title:

Plexin a2 / semaphorin 6a complex

Structure:

Semaphorin-6a. Chain: a. Fragment: sema and psi domain (unp residues 19-570). Synonym: semaphorin via, sema via, semaphorin-6a-1, sema6a-1, semaphorin q, sema q. Engineered: yes. Plexin-a2. Chain: b. Fragment: sema and psi domain (unp residues 31-561).

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: sema6a, semaq. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: cho lec 3.2.8.1. Gene: plxna2, kiaa0463. Expressed in: homo sapiens.

Resolution:

3.60Å

R-factor:

0.233

R-free:

0.287

Authors:

T.Nogi,N.Yasui,E.Mihara,J.Takagi

Key ref:

T.Nogi et al. (2010). Structural basis for semaphorin signalling through the plexin receptor. Nature, 467, 1123-1127. PubMed id: 20881961

Date:

28-Jul-10

Release date:

06-Oct-10

PROCHECK

	Headers

	References

Protein chain

O35464 (SEM6A_MOUSE) - Semaphorin-6A from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:					1031 a.a. 537 a.a.

Protein chain

P70207 (PLXA2_MOUSE) - Plexin-A2 from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					1894 a.a. 499 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

	Nature 467:1123-1127 (2010)
PubMed id: 20881961

Structural basis for semaphorin signalling through the plexin receptor.
T.Nogi, N.Yasui, E.Mihara, Y.Matsunaga, M.Noda, N.Yamashita, T.Toyofuku, S.Uchiyama, Y.Goshima, A.Kumanogoh, J.Takagi.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23104057

B.J.Janssen, T.Malinauskas, G.A.Weir, M.Z.Cader, C.Siebold, and E.Y.Jones (2012).
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Nat Struct Mol Biol, 19, 1293-1299.

PDB codes:

4gz8 4gz9 4gza

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.