PDBsum entry 3afc

Signaling protein

PDB id

3afc

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Contents

			Protein chains

					534 a.a. *


					499 a.a. *

			Ligands

					NAG-NAG ×2


					NAG ×2

			Waters ×194

* Residue conservation analysis

PDB id:

3afc

Links

Name:

Signaling protein

Title:

Mouse semaphorin 6a extracellular domain

Structure:

Semaphorin-6a. Chain: a, b. Fragment: sema and psi domain (unp residues 19-570). Synonym: semaphorin via, sema via, semaphorin-6a-1, sema6a-1, semaphorin q, sema q. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: sema6a, semaq. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.

Resolution:

2.50Å

R-factor:

0.215

R-free:

0.278

Authors:

N.Yasui,T.Nogi,E.Mihara,J.Takagi

Key ref:

T.Nogi et al. (2010). Structural basis for semaphorin signalling through the plexin receptor. Nature, 467, 1123-1127. PubMed id: 20881961

Date:

26-Feb-10

Release date:

06-Oct-10

PROCHECK

	Headers

	References

Protein chain

O35464 (SEM6A_MOUSE) - Semaphorin-6A from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:					1031 a.a. 534 a.a.

Protein chain

O35464 (SEM6A_MOUSE) - Semaphorin-6A from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:					1031 a.a. 499 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

	Nature 467:1123-1127 (2010)
PubMed id: 20881961

Structural basis for semaphorin signalling through the plexin receptor.
T.Nogi, N.Yasui, E.Mihara, Y.Matsunaga, M.Noda, N.Yamashita, T.Toyofuku, S.Uchiyama, Y.Goshima, A.Kumanogoh, J.Takagi.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23104057

B.J.Janssen, T.Malinauskas, G.A.Weir, M.Z.Cader, C.Siebold, and E.Y.Jones (2012).
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Nat Struct Mol Biol, 19, 1293-1299.

PDB codes:

4gz8 4gz9 4gza

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.