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PDBsum entry 3ads

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protein ligands Protein-protein interface(s) links
Transcription PDB id
3ads
Jmol
Contents
Protein chain
262 a.a. *
Ligands
IMN ×3
Waters ×97
* Residue conservation analysis
PDB id:
3ads
Name: Transcription
Title: Human ppargamma ligand-binding domain in complex with indome
Structure: Peroxisome proliferator-activated receptor gamma. Chain: a, b. Fragment: ligand-binding domain, residues in unp 223-505. Synonym: ppar-gamma, nuclear receptor subfamily 1 group c m engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppargamma. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.25Å     R-factor:   0.228     R-free:   0.277
Authors: T.Waku,T.Shiraki,T.Oyama,K.Morikawa
Key ref: T.Waku et al. (2010). The nuclear receptor PPARĪ³ individually responds to serotonin- and fatty acid-metabolites. EMBO J, 29, 3395-3407. PubMed id: 20717101
Date:
29-Jan-10     Release date:   22-Dec-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P37231  (PPARG_HUMAN) -  Peroxisome proliferator-activated receptor gamma
Seq:
Struc:
505 a.a.
262 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     4 terms  

 

 
EMBO J 29:3395-3407 (2010)
PubMed id: 20717101  
 
 
The nuclear receptor PPARĪ³ individually responds to serotonin- and fatty acid-metabolites.
T.Waku, T.Shiraki, T.Oyama, K.Maebara, R.Nakamori, K.Morikawa.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23354045 C.Kim, J.Wong, J.Wen, S.Wang, C.Wang, S.Spiering, N.G.Kan, S.Forcales, P.L.Puri, T.C.Leone, J.E.Marine, H.Calkins, D.P.Kelly, D.P.Judge, and H.S.Chen (2013).
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.
  Nature, 494, 105-110.  
21494145 H.Watanabe, M.T.Rose, and H.Aso (2011).
Role of peripheral serotonin in glucose and lipid metabolism.
  Curr Opin Lipidol, 22, 186-191.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.