PDBsum entry 3a8c

Hydrolase

PDB id: 3a8c

Contents

Protein chain

223 a.a. *

Ligands

O09

Metals

_CA

Waters ×201

* Residue conservation analysis

PDB id:

3a8c

Name:

Hydrolase

Title:

Crystal structure of trypsin complexed with (e)-2-(4- carbamimidoylbenzylideneaminooxy)acetic acid (soaking with mixture of [(e)-2-(4-carbamimidoylbenzylideneaminooxy)acetic acid] and [(e)-2- (4-carbamimidoylbenzylideneaminooxy)-2-methylpropanoic acid])

Structure:

Cationic trypsin. Chain: a. Synonym: beta-trypsin, alpha-trypsin chain 1, alpha-trypsin chain 2. Ec: 3.4.21.4

Source:

Bos taurus. Bovine. Organism_taxid: 9913

Resolution:

1.85Å R-factor: 0.154 R-free: 0.190

Authors:

J.Yamane,M.Yao,I.Tanaka

Key ref:

J.Yamane et al. In-Crystal chemical ligation for drug discovery. To be published, .

Date:

05-Oct-09 Release date: 29-Sep-10

Protein chain

P00760  (TRY1_BOVIN) -  Serine protease 1 from Bos taurus

Seq: 246 a.a.

Struc: 223 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.21.4 - trypsin.
• Reaction: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.