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PDBsum entry 3w2p

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protein ligands links
Transferase/transferase inhibitor PDB id
3w2p
Jmol
Contents
Protein chain
308 a.a.
Ligands
W2P
Waters ×104
PDB id:
3w2p
Name: Transferase/transferase inhibitor
Title: Egfr kinase domain t790m/l858r mutant with compound 2
Structure: Epidermal growth factor receptor. Chain: a. Fragment: kinase domain, unp residues 698-1022. Synonym: proto-oncogenE C-erbb-1, receptor tyrosine-protein erbb-1. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Resolution:
2.05Å     R-factor:   0.181     R-free:   0.206
Authors: S.Sogabe,Y.Kawakita,S.Igaki
Key ref: S.Sogabe et al. Structure-Based approach for the discovery of pyrrolo[3,2-D]pyrimidine-Based egfr t790m/l858r mutan inhibitors. Acs med.Chem.Lett., . DOI: 10.1021/ML300327Z
Date:
03-Dec-12     Release date:   16-Jan-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1210 a.a.
308 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.7.10.1  - Receptor protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP
+ [protein]-L-tyrosine
= ADP
+ [protein]-L-tyrosine phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     4 terms