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PDBsum entry 3sd0

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protein ligands Protein-protein interface(s) links
Transferase/transferase inhibitor PDB id
3sd0
Jmol
Contents
Protein chain
350 a.a.
Ligands
TSK ×2
EPE ×2
Waters ×284
PDB id:
3sd0
Name: Transferase/transferase inhibitor
Title: Identification of a glycogen synthase kinase-3b inhibitor th attenuates hyperactivity in clock mutant mice
Structure: Glycogen synthase kinase-3 beta. Chain: a, b. Fragment: unp residues 35-384. Synonym: gsk-3 beta. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
2.70Å     R-factor:   0.179     R-free:   0.254
Authors: A.M.Mesecar,R.L.Walters
Key ref: A.M.Mesecar and r.l.walters Identification of a glycogen synthase kinase-3b inhib that attenuates hyperactivity in clock mutant mice. To be published, .
Date:
08-Jun-11     Release date:   03-Aug-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P49841  (GSK3B_HUMAN) -  Glycogen synthase kinase-3 beta
Seq:
Struc:
420 a.a.
350 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 1: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
   Enzyme class 2: E.C.2.7.11.26  - [Tau protein] kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + [tau protein] = ADP + [tau protein] phosphate
ATP
+ [tau protein]
= ADP
+ [tau protein] phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     4 terms