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PDBsum entry 3s41

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protein ligands metals links
Transferase PDB id
3s41
Jmol
Contents
Protein chain
448 a.a.
Ligands
GLC
S41
Metals
_NA
Waters ×181
PDB id:
3s41
Name: Transferase
Title: Glucokinase in complex with activator and glucose
Structure: Glucokinase. Chain: a. Fragment: sequence database residues 12-465. Synonym: hexokinase type iv, hk iv, hexokinase-4, hk4, hexo engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.18Å     R-factor:   0.193     R-free:   0.246
Authors: S.Liu
Key ref: J.A.Pfefferkorn et al. (2011). Designing glucokinase activators with reduced hypogly risk: discovery of n,N-Dimethyl-5-(2-Methyl-6-((5-Methylpyrazin-2-Yl)- Carbamoyl)benzofuran-4-Yloxy)pyrimidine-2-Carboxamide clinical candidate for the treatment of type 2 diabet mellitus. Medchemcomm, 2, 828.
Date:
18-May-11     Release date:   14-Sep-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P35557  (HXK4_HUMAN) -  Glucokinase
Seq:
Struc:
465 a.a.
448 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 8 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.2  - Glucokinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate
ATP
+
D-glucose
Bound ligand (Het Group name = GLC)
corresponds exactly
= ADP
+ D-glucose 6-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   9 terms 
  Biological process     metabolic process   36 terms 
  Biochemical function     catalytic activity     15 terms