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PDBsum entry 3s37

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protein Protein-protein interface(s) links
Immune system/transferase PDB id
3s37
Jmol
Contents
Protein chains
212 a.a.
209 a.a.
110 a.a.
PDB id:
3s37
Name: Immune system/transferase
Title: Structural basis for the function of two anti-vegf receptor
Structure: 1121b fab light chain. Chain: l. Engineered: yes. 1121b fab heavy chain. Chain: h. Engineered: yes. Vascular endothelial growth factor receptor 2. Chain: x. Fragment: domain 3 of vegf receptor 2, unp residues 220-338
Source: Mus musculus, homo sapiens. Mouse, human. Organism_taxid: 10090, 9606. Expressed in: human. Expression_system_taxid: 9606. Expression_system_cell_line: mammalian kidney cells hek293. Homo sapiens. Human. Organism_taxid: 9606.
Resolution:
2.70Å     R-factor:   0.284     R-free:   0.315
Authors: M.C.Franklin
Key ref: M.C.Franklin et al. (2011). The structural basis for the function of two anti-VEGF receptor 2 antibodies. Structure, 19, 1097-1107. PubMed id: 21827946 DOI: 10.1016/j.str.2011.01.019
Date:
17-May-11     Release date:   24-Aug-11    
PROCHECK
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 Headers
 References

Protein chain
No UniProt id for this chain
Struc: 212 a.a.
Protein chain
No UniProt id for this chain
Struc: 209 a.a.
Protein chain
Pfam   ArchSchema ?
P35968  (VGFR2_HUMAN) -  Vascular endothelial growth factor receptor 2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1356 a.a.
110 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chain X: E.C.2.7.10.1  - Receptor protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP
+ [protein]-L-tyrosine
= ADP
+ [protein]-L-tyrosine phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     integral to membrane   1 term 
  Biological process     vascular endothelial growth factor receptor signaling pathway   2 terms 
  Biochemical function     growth factor binding     3 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.str.2011.01.019 Structure 19:1097-1107 (2011)
PubMed id: 21827946  
 
 
The structural basis for the function of two anti-VEGF receptor 2 antibodies.
M.C.Franklin, E.C.Navarro, Y.Wang, S.Patel, P.Singh, Y.Zhang, K.Persaud, A.Bari, H.Griffith, L.Shen, P.Balderes, P.Kussie.
 
  ABSTRACT  
 
No abstract given.