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PDBsum entry 3rut

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protein ligands Protein-protein interface(s) links
Transcription regulator PDB id
3rut
Jmol
Contents
Protein chains
229 a.a.
11 a.a.
Ligands
SO4 ×2
59G
Waters ×13
PDB id:
3rut
Name: Transcription regulator
Title: Fxr with src1 and gsk359
Structure: Bile acid receptor. Chain: a. Fragment: ligand binding domain (unp residues 258-486). Synonym: fxr, farnesoid x-activated receptor, farnesol rece 1, nuclear receptor subfamily 1 group h member 4, retinoid receptor-interacting protein 14, rxr-interacting protein 14 engineered: yes. Nuclear receptor coactivator 1. Chain: b.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bar, fxr, hrr1, nr1h4, rip14. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Resolution:
3.00Å     R-factor:   0.234     R-free:   0.266
Authors: S.P.Williams,K.P.Madauss
Key ref: A.Akwabi-Ameyaw et al. (2011). Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene. Bioorg Med Chem Lett, 21, 6154-6160. PubMed id: 21890356 DOI: 10.1016/j.bmcl.2011.08.034
Date:
05-May-11     Release date:   21-Sep-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q96RI1  (NR1H4_HUMAN) -  Bile acid receptor
Seq:
Struc:
486 a.a.
229 a.a.
Protein chain
Pfam   ArchSchema ?
Q15788  (NCOA1_HUMAN) -  Nuclear receptor coactivator 1
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1441 a.a.
11 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chain B: E.C.2.3.1.48  - Histone acetyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
Acetyl-CoA
+ [histone]
= CoA
+ acetyl-[histone]
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     4 terms  

 

 
    Added reference    
 
 
DOI no: 10.1016/j.bmcl.2011.08.034 Bioorg Med Chem Lett 21:6154-6160 (2011)
PubMed id: 21890356  
 
 
Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.
A.Akwabi-Ameyaw, J.A.Caravella, L.Chen, K.L.Creech, D.N.Deaton, K.P.Madauss, H.B.Marr, A.B.Miller, F.Navas, D.J.Parks, P.K.Spearing, D.Todd, S.P.Williams, G.B.Wisely.
 
  ABSTRACT  
 
No abstract given.