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PDBsum entry 3ro2

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protein ligands Protein-protein interface(s) links
Protein binding PDB id
3ro2
Jmol
Contents
Protein chains
328 a.a.
22 a.a.
Ligands
GOL ×3
Waters ×103
PDB id:
3ro2
Name: Protein binding
Title: Structures of the lgn/numa complex
Structure: G-protein-signaling modulator 2. Chain: a. Fragment: tpr domain, unp residues 22-357. Synonym: pins homolog. Engineered: yes. Peptide of nuclear mitotic apparatus protein 1. Chain: b. Fragment: unp residues 1899-1926. Synonym: numa protein, sp-h antigen.
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: gpsm2, lgn, pins. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Human.
Resolution:
2.30Å     R-factor:   0.218     R-free:   0.271
Authors: Y.Shang,Z.Wei
Key ref: J.Zhu et al. (2011). LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Mol Cell, 43, 418-431. PubMed id: 21816348 DOI: 10.1016/j.molcel.2011.07.011
Date:
25-Apr-11     Release date:   07-Mar-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q8VDU0  (GPSM2_MOUSE) -  G-protein-signaling modulator 2
Seq:
Struc:
 
Seq:
Struc:
679 a.a.
328 a.a.*
Protein chain
Pfam   ArchSchema ?
Q14980  (NUMA1_HUMAN) -  Nuclear mitotic apparatus protein 1
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
2115 a.a.
22 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     regulation of G-protein coupled receptor protein signaling pathway   1 term 
  Biochemical function     GDP-dissociation inhibitor activity     1 term  

 

 
DOI no: 10.1016/j.molcel.2011.07.011 Mol Cell 43:418-431 (2011)
PubMed id: 21816348  
 
 
LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways.
J.Zhu, W.Wen, Z.Zheng, Y.Shang, Z.Wei, Z.Xiao, Z.Pan, Q.Du, W.Wang, M.Zhang.
 
  ABSTRACT  
 
No abstract given.