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PDBsum entry 3poz

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protein ligands links
Transferase/transferase inhibitor PDB id
3poz
Jmol
Contents
Protein chain
293 a.a.
Ligands
SO4 ×3
03P
Waters ×126
PDB id:
3poz
Name: Transferase/transferase inhibitor
Title: Egfr kinase domain complexed with tak-285
Structure: Epidermal growth factor receptor. Chain: a. Fragment: residues 606-1022. Synonym: proto-oncogenE C-erbb-1, receptor tyrosine-protein erbb-1. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7118.
Resolution:
1.50Å     R-factor:   0.220     R-free:   0.243
Authors: K.Aertgeerts,R.Skene,S.Sogabe
Key ref: K.Aertgeerts et al. (2011). Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein. J Biol Chem, 286, 18756-18765. PubMed id: 21454582 DOI: 10.1074/jbc.M110.206193
Date:
23-Nov-10     Release date:   30-Mar-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1210 a.a.
293 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.10.1  - Receptor protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP
+ [protein]-L-tyrosine
= ADP
+ [protein]-L-tyrosine phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     4 terms  

 

 
    reference    
 
 
DOI no: 10.1074/jbc.M110.206193 J Biol Chem 286:18756-18765 (2011)
PubMed id: 21454582  
 
 
Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.
K.Aertgeerts, R.Skene, J.Yano, B.C.Sang, H.Zou, G.Snell, A.Jennings, K.Iwamoto, N.Habuka, A.Hirokawa, T.Ishikawa, T.Tanaka, H.Miki, Y.Ohta, S.Sogabe.
 
  ABSTRACT  
 
No abstract given.