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PDBsum entry 3pdo

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protein ligands Protein-protein interface(s) links
Immune system PDB id
3pdo
Jmol
Contents
Protein chains
185 a.a. *
191 a.a. *
17 a.a. *
Ligands
GOL ×2
FMT
Waters ×320
* Residue conservation analysis
PDB id:
3pdo
Name: Immune system
Title: Crystal structure of hla-dr1 with clip102-120
Structure: Hla class ii histocompatibility antigen, dr alpha chain: a. Fragment: extracellular domain. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 b chain: b. Fragment: extracellular domain. Synonym: mhc class ii antigen drb1 1, Dr-1, dr1.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: hla-drb1. Synthetic: yes. Organism_taxid: 9606
Resolution:
1.95Å     R-factor:   0.194     R-free:   0.240
Authors: S.Gunther,A.Schlundt,J.Sticht,Y.Roske,U.Heinemann,K.-H.Wiesm G.Jung,K.Falk,O.Rotzschke,C.Freund
Key ref: S.Günther et al. (2010). Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc Natl Acad Sci U S A, 107, 22219-22224. PubMed id: 21115828
Date:
23-Oct-10     Release date:   08-Dec-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain
Seq:
Struc:
254 a.a.
185 a.a.*
Protein chain
Pfam   ArchSchema ?
P04229  (2B11_HUMAN) -  HLA class II histocompatibility antigen, DRB1-1 beta chain
Seq:
Struc:
266 a.a.
191 a.a.*
Protein chain
Pfam   ArchSchema ?
P04233  (HG2A_HUMAN) -  HLA class II histocompatibility antigen gamma chain
Seq:
Struc:
296 a.a.
17 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   2 terms 
  Biological process     immune response   2 terms 

 

 
Proc Natl Acad Sci U S A 107:22219-22224 (2010)
PubMed id: 21115828  
 
 
Bidirectional binding of invariant chain peptides to an MHC class II molecule.
S.Günther, A.Schlundt, J.Sticht, Y.Roske, U.Heinemann, K.H.Wiesmüller, G.Jung, K.Falk, O.Rötzschke, C.Freund.
 
  ABSTRACT  
 
No abstract given.