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PDBsum entry 3p0m

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protein ligands Protein-protein interface(s) links
Transferase PDB id
3p0m
Jmol
Contents
Protein chains
337 a.a.
19 a.a.
Ligands
4SB
Waters ×218
PDB id:
3p0m
Name: Transferase
Title: Human camp-dependent protein kinase in complex with an inhib
Structure: Camp-dependent protein kinase catalytic subunit a chain: a. Synonym: pka c-alpha. Engineered: yes. Camp-dependent protein kinase inhibitor alpha. Chain: b. Fragment: residues 5-24. Synonym: pki-alpha, camp-dependent protein kinase inhibitor muscle/brain isoform.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prkaca, pkaca. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Resolution:
2.03Å     R-factor:   0.171     R-free:   0.205
Authors: H.Koester,A.Heine,G.Klebe
Key ref: H.Koester et al. Fragment based drug design on pka. To be published, .
Date:
29-Sep-10     Release date:   28-Sep-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P17612  (KAPCA_HUMAN) -  cAMP-dependent protein kinase catalytic subunit alpha
Seq:
Struc:
351 a.a.
337 a.a.*
Protein chain
Pfam   ArchSchema ?
P61925  (IPKA_HUMAN) -  cAMP-dependent protein kinase inhibitor alpha
Seq:
Struc:
76 a.a.
19 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chain A: E.C.2.7.11.11  - cAMP-dependent protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     neuromuscular junction   15 terms 
  Biological process     intracellular signal transduction   51 terms 
  Biochemical function     nucleotide binding     12 terms