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PDBsum entry 3op0

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protein ligands metals Protein-protein interface(s) links
Signaling protein/signaling protein regu PDB id
3op0
Jmol
Contents
Protein chains
321 a.a. *
Ligands
LEU-GLN-ARG-PTR-
SER-SER-ASP-PRO-
THR-GLY
×2
Metals
_NI ×2
_NA ×2
Waters ×282
* Residue conservation analysis
PDB id:
3op0
Name: Signaling protein/signaling protein regu
Title: Crystal structure of cbl-c (cbl-3) tkb domain in complex wit py1069 peptide
Structure: Signal transduction protein cbl-c. Chain: a, b. Fragment: cbl n-terminal, unp residues 9-323. Synonym: sh3-binding protein cbl-c, sh3-binding protein cbl finger protein 57. Engineered: yes. Mutation: yes. Epidermal growth factor receptor. Chain: c, d.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cbl3, cblc, rnf57. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Resolution:
2.52Å     R-factor:   0.216     R-free:   0.266
Authors: A.Chaikuad,K.Guo,C.D.O.Cooper,V.Ayinampudi,T.Krojer,E.Ugochu J.R.C.Muniz,M.Vollmar,P.Canning,F.Von Delft,C.H.Arrowsmith, J.Weigelt,A.M.Edwards,C.Bountra,A.Bullock,Structural Genomi Consortium (Sgc)
Key ref: A.Chaikuad et al. Crystal structure of cbl-C (cbl-3) tkb domain in comp with egfr py1069 peptide. To be published, .
Date:
31-Aug-10     Release date:   20-Oct-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9ULV8  (CBLC_HUMAN) -  E3 ubiquitin-protein ligase CBL-C
Seq:
Struc:
474 a.a.
321 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 11 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     regulation of signaling   2 terms 
  Biochemical function     signal transducer activity     4 terms