spacer
spacer

PDBsum entry 3nuu

Go to PDB code: 
protein ligands links
Transferase PDB id
3nuu
Jmol
Contents
Protein chain
277 a.a.
Ligands
GOL ×4
SO4 ×10
JOZ
Waters ×135
PDB id:
3nuu
Name: Transferase
Title: Phosphoinositide-dependent kinase-1 (pdk1) with fragment11
Structure: Pkb-like. Chain: a. Fragment: unp residues 65-350. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkb-like 1. Expressed in: baculovirus. Expression_system_taxid: 10469
Resolution:
1.98Å     R-factor:   0.189     R-free:   0.239
Authors: N.Campobasso,P.Ward
Key ref: J.R.Medina et al. (2010). Aminoindazole pdk1 inhibitors: a case study in fragment-Based drug discovery. Acs med.Chem.Lett., 1, 439.
Date:
07-Jul-10     Release date:   25-May-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
O15530  (PDPK1_HUMAN) -  3-phosphoinositide-dependent protein kinase 1
Seq:
Struc:
 
Seq:
Struc:
556 a.a.
277 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     4 terms