PDBsum entry: 3mdx

Hydrolase

PDB id: 3mdx

Contents

Protein chain

139 a.a. *

Ligands

EDO

Waters ×181

* Residue conservation analysis

PDB id:

3mdx

Name:

Hydrolase

Title:

Crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from brucella melitensis, rhombohedral crystal form

Structure:

Deoxyuridine 5'-triphosphate nucleotidohydrolase. Chain: a. Synonym: dutpase, dutp pyrophosphatase. Engineered: yes

Source:

Brucella melitensis. Organism_taxid: 359391. Strain: 2308. Gene: dut, bab1_1687. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.45Å R-factor: 0.151 R-free: 0.167

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

J.Abendroth et al. Crystal structure of deoxyuridine 5-Triphosphate nucleotidohydrolase from brucella melitensis, Rhombohedral crystal form. To be published,

Date:

31-Mar-10 Release date: 21-Apr-10

Protein chain

Q2YRG4  (DUT_BRUA2) -  Deoxyuridine 5'-triphosphate nucleotidohydrolase

Seq: 157 a.a.

Struc: 139 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.1.23 - dUTP diphosphatase.
• Reaction: dUTP + H₂O = dUMP + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: nucleotide metabolic process (2 terms)
• Biochemical function: hydrolase activity (3 terms)