PDBsum entry: 3jst

Lyase

PDB id: 3jst

Contents

Protein chains

97 a.a. *

Ligands

EDO ×2

Waters ×196

* Residue conservation analysis

PDB id:

3jst

Name:

Lyase

Title:

Crystal structure of transcriptional coactivator/pterin dehy from brucella melitensis

Structure:

Putative pterin-4-alpha-carbinolamine dehydratase chain: a, b. Synonym: phs, 4-alpha-hydroxy-tetrahydropterin dehydratase, carbinolamine dehydratase, pcd. Engineered: yes

Source:

Brucella melitensis. Organism_taxid: 29459. Gene: phhb, bmei1864. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.10Å R-factor: 0.182 R-free: 0.218

Authors:

Seattle Structural Genomics Center For Infectious Disease (S

Key ref:

Seattle structural genomics center for infectious dis(ssgcid) Crystal structure of transcriptional coactivator/pter dehydratase from brucella melitensis. To be published,

Date:

10-Sep-09 Release date: 22-Sep-09

Protein chains

P65722  (PHS_BRUME) -  Putative pterin-4-alpha-carbinolamine dehydratase

Seq: 97 a.a.

Struc: 97 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.96 - 4a-hydroxytetrahydrobiopterin dehydratase.
• Pathway: Biopterin Biosynthesis
• Reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro- 4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro- 6H-pterin + H₂O

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: tetrahydrobiopterin biosynthetic process (1 term)
• Biochemical function: lyase activity (2 terms)