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Lyase PDB-id
3js3
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253 a.a.
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DHS ×4
Waters ×322
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PDB id: 3js3
Name: Lyase
Title: Crystal structure of type i 3-dehydroquinate dehydratase (arod) from clostridium difficile with covalent reaction intermediate

Structure:
3-dehydroquinate dehydratase. Chain: a, b, c, d. Synonym: 3-dehydroquinase, type i dhqase. Engineered: yes

Source:
Clostridium difficile 630. Organism_taxid: 272563. Strain: 630. Gene: arod, cd2217. Expressed in: escherichia coli. Expression_system_taxid: 562.

Enzyme class:
E.C.4.2.1.10   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Reaction:
3-dehydroquinate = 3-dehydroshikimate + H2O (see diagram below)

Pathway:
Shikimate and Chorismate Biosynthesis

Resolution:
2.20Å

R-factor:
0.192

R-free:
0.241

Authors:
G.Minasov,S.H.Light,L.Shuvalova,I.Dubrovska,J.Winsor, P.Scott,W.F.Anderson,Center For Structural Genomics Of Infectious Diseases (Csgid)

Date:
09-Sep-09

Release date:
22-Sep-09

Related entries:
Idp90163 related db: targetdb
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Enzyme reaction for E.C.4.2.1.10


3-dehydroquinate
=
3-dehydroshikimate
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.