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Transferase PDB-id
3ix6
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244 a.a.
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PDB id: 3ix6
Name: Transferase
Title: Crystal structure of thymidylate synthase thya from brucella melitensis

Structure:
Thymidylate synthase. Chain: a, b. Synonym: ts, tsase. Engineered: yes

Source:
Brucella melitensis. Organism_taxid: 29459. Gene: thya, bmei0608. Expressed in: escherichia coli. Expression_system_taxid: 562.

Enzyme class:
E.C.2.1.1.45   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Reaction:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP (see diagram below)

Pathway:
Folate Coenzymes

Resolution:
2.20Å

R-factor:
0.215

R-free:
0.245

Authors:
Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Date:
03-Sep-09

Release date:
22-Sep-09

Related entries:
Brmea.00249.A related db: targetdb
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Enzyme reaction for E.C.2.1.1.45


5,10-methylenetetrahydrofolate
+
dUMP
=
dihydrofolate
+
dTMP
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.