PDBsum entry: 3ix6

Transferase

PDB id: 3ix6

Contents

Protein chains

244 a.a. *

Waters ×230

* Residue conservation analysis

PDB id:

3ix6

Name:

Transferase

Title:

Crystal structure of thymidylate synthase thya from brucella melitensis

Structure:

Thymidylate synthase. Chain: a, b. Synonym: ts, tsase. Engineered: yes

Source:

Brucella melitensis. Organism_taxid: 29459. Gene: thya, bmei0608. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.20Å R-factor: 0.215 R-free: 0.245

Authors:

Seattle Structural Genomics Center For Infectious Disease (S

Key ref:

J.Abendroth et al. Crystal structure of thymidylate synthase thya from b melitensis. To be published,

Date:

03-Sep-09 Release date: 22-Sep-09

Protein chains

P67042  (TYSY_BRUME) -  Thymidylate synthase

Seq: 264 a.a.

Struc: 244 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.1.45 - Thymidylate synthase.
• Pathway: Folate Coenzymes
• Reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (1 term)
• Biological process: methylation (3 terms)
• Biochemical function: protein binding (4 terms)