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PDBsum entry 3it8

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protein ligands Protein-protein interface(s) links
Immune system PDB id
3it8
Jmol
Contents
Protein chains
(+ 0 more) 152 a.a. *
(+ 0 more) 299 a.a. *
Ligands
NAG ×18
Waters ×96
* Residue conservation analysis
PDB id:
3it8
Name: Immune system
Title: Crystal structure of tnf alpha complexed with a poxvirus mhc tnf binding protein
Structure: Tumor necrosis factor. Chain: a, b, c, g, h, i. Fragment: tumor necrosis factor, soluble form, unp residues synonym: tnf-alpha, tumor necrosis factor ligand superfamil 2, tnf-a, cachectin, tumor necrosis factor, membrane form, necrosis factor, soluble form. Engineered: yes. 2l protein. Chain: d, e, f, j, k, l.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnf. Expressed in: escherichia coli. Expression_system_taxid: 562. Yaba-like disease virus. Yldv. Organism_taxid: 132475.
Resolution:
2.80Å     R-factor:   0.236     R-free:   0.266
Authors: Z.Yang,A.P.West Jr.,P.J.Bjorkman
Key ref: Z.Yang et al. Crystal structure of tnfa complexed with a poxvirus mhc-Related tnf binding protein. Nat.Struct.Mol.Biol., .
Date:
27-Aug-09     Release date:   20-Oct-09    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01375  (TNFA_HUMAN) -  Tumor necrosis factor
Seq:
Struc:
233 a.a.
152 a.a.*
Protein chains
Pfam   ArchSchema ?
Q9DHW0  (Q9DHW0_YLDV) -  2L protein
Seq:
Struc:
338 a.a.
299 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   1 term 
  Biological process     immune response   1 term 
  Biochemical function     tumor necrosis factor receptor binding     1 term