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PDBsum entry 3ipe

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protein ligands Protein-protein interface(s) links
Hormone PDB id
3ipe
Jmol
Contents
Protein chain
115 a.a. *
Ligands
JZE
Waters ×138
* Residue conservation analysis
PDB id:
3ipe
Name: Hormone
Title: Human transthyretin (ttr) complexed with a palindromic bival amyloid inhibitor (7 carbon linker).
Structure: Transthyretin. Chain: a, b. Fragment: unp residues 21-147. Synonym: prealbumin, tbpa, ttr, attr
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
1.40Å     R-factor:   0.176     R-free:   0.196
Authors: S.E.Kolstoe,S.P.Wood,M.B.Pepys
Key ref: S.E.Kolstoe et al. (2010). Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc Natl Acad Sci U S A, 107, 20483-20488. PubMed id: 21059958
Date:
17-Aug-09     Release date:   17-Nov-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P02766  (TTHY_HUMAN) -  Transthyretin
Seq:
Struc:
147 a.a.
115 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   4 terms 
  Biological process     transport   5 terms 
  Biochemical function     protein binding     5 terms  

 

 
Proc Natl Acad Sci U S A 107:20483-20488 (2010)
PubMed id: 21059958  
 
 
Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
S.E.Kolstoe, P.P.Mangione, V.Bellotti, G.W.Taylor, G.A.Tennent, S.Deroo, A.J.Morrison, A.J.Cobb, A.Coyne, M.G.McCammon, T.D.Warner, J.Mitchell, R.Gill, M.D.Smith, S.V.Ley, C.V.Robinson, S.P.Wood, M.B.Pepys.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21267559 R.H.Falk, and S.Dorbala (2011).
Pursuing an underdiagnosed disease: a simple imaging test for increasing suspicion of cardiac amyloidosis.
  Eur J Nucl Med Mol Imaging, 38, 467-469.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.