PDBsum entry: 3ecd

Transferase

PDB id: 3ecd

Contents

Protein chains

387 a.a. *

Ligands

GOL ×4

Waters ×1607

* Residue conservation analysis

PDB id:

3ecd

Name:

Transferase

Title:

Crystal structure of serine hydroxymethyltransferase from bu pseudomallei

Structure:

Serine hydroxymethyltransferase 2. Chain: a, b, c, d. Synonym: serine methylase 2, shmt 2. Engineered: yes

Source:

Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: glya2, bpss0547. Expressed in: escherichia coli.

Resolution:

1.60Å R-factor: 0.188 R-free: 0.206

Authors:

Seattle Structural Genomics Center For Infectious Disease (S

Key ref:

Seattle structural genomics center for infectiousdisease (ssgcid) Crystal structure of serine hydroxymethyltransferase from burkholderia pseudomallei. To be published,

Date:

29-Aug-08 Release date: 09-Sep-08

Protein chains

Q3JGP5  (GLYA2_BURP1) -  Serine hydroxymethyltransferase 2

Seq: 424 a.a.

Struc: 387 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.2.1 - Glycine hydroxymethyltransferase.
• Pathway: Folate Coenzymes
• Reaction: 5,10-methylenetetrahydrofolate + glycine + H₂O = tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine (Bound ligand (Het Group name = GOL) matches with 62.50% similarity)

• Cofactor: Pyridoxal 5'-phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (1 term)
• Biological process: one-carbon metabolic process (4 terms)
• Biochemical function: catalytic activity (4 terms)