PDBsum entry: 3ecd

Transferase

PDB-id: 3ecd

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Description

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Protein chains

387 a.a. *

Ligands

GOL ×4

Waters ×1607

* Residue conservation analysis

Tools

Clefts Calculation

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PDB id:

3ecd

Name:

Transferase

Title:

Crystal structure of serine hydroxymethyltransferase from burkholderia pseudomallei

Structure:

Serine hydroxymethyltransferase 2. Chain: a, b, c, d. Synonym: serine methylase 2, shmt 2. Engineered: yes

Source:

Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: glya2, bpss0547. Expressed in: escherichia coli.

UniProt:

Chains A, B, C, D: Q3JGP5 (GLYA2_BURP1)

Seq:

Struc:

Seq:

424 a.a.

Struc:

387 a.a.

Key:	PfamA domain
Secondary structure	CATH domain

Enzyme class:

E.C.2.1.2.1   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Reaction:

5,10-methylenetetrahydrofolate + glycine + H₂O = tetrahydrofolate + L-serine (see diagram below)

Cofactor:

Pyridoxal-phosphate

Pathway:

Folate Coenzymes

Resolution:

1.60Å

R-factor:

0.188

R-free:

0.206

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

seattle structural genomics center for infectiousdisease (ssgcid) crystal structure of serine hydroxymethyltransferase from burkholderia pseudomallei. TO BE PUBLISHED, .

Date:

29-Aug-08

Release date:

09-Sep-08

Related entries:

Bupsa00008a related db: targetdb

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