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PDBsum entry 3ask

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protein ligands metals Protein-protein interface(s) links
Ligase/DNA binding protein PDB id
3ask
Jmol
Contents
Protein chains
213 a.a.
154 a.a.
Ligands
ALA-ARG-THR-LYS-
GLN-THR-ALA-ARG-
M3L-SER
ALA-ARG-THR-LYS-
GLN-THR-ALA-ARG-
M3L
M3L
Metals
_ZN ×7
Waters ×4
PDB id:
3ask
Name: Ligase/DNA binding protein
Title: Structure of uhrf1 in complex with histone tail
Structure: E3 ubiquitin-protein ligase uhrf1. Chain: a, b, c, d. Fragment: tandem tudor domain, phd finger (residues 134-366 engineered: yes. Mutation: yes. Histone h3.3. Chain: p, q, r. Fragment: residues in unp 2-14. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: uhrf1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Resolution:
2.90Å     R-factor:   0.248     R-free:   0.286
Authors: K.Arita,K.Sugita,M.Unoki,R.Hamamoto,N.Sekiyama,H.Tochio,M.Ar M.Shirakawa
Key ref: K.Arita et al. (2012). Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1. Proc Natl Acad Sci U S A, 109, 12950-12955. PubMed id: 22837395 DOI: 10.1073/pnas.1203701109
Date:
16-Dec-10     Release date:   25-Jan-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q96T88  (UHRF1_HUMAN) -  E3 ubiquitin-protein ligase UHRF1
Seq:
Struc:
 
Seq:
Struc:
793 a.a.
213 a.a.*
Protein chains
Pfam   ArchSchema ?
Q96T88  (UHRF1_HUMAN) -  E3 ubiquitin-protein ligase UHRF1
Seq:
Struc:
 
Seq:
Struc:
793 a.a.
154 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     zinc ion binding     1 term  

 

 
DOI no: 10.1073/pnas.1203701109 Proc Natl Acad Sci U S A 109:12950-12955 (2012)
PubMed id: 22837395  
 
 
Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.
K.Arita, S.Isogai, T.Oda, M.Unoki, K.Sugita, N.Sekiyama, K.Kuwata, R.Hamamoto, H.Tochio, M.Sato, M.Ariyoshi, M.Shirakawa.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23211769 C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.
  Nat Struct Mol Biol, 19, 1218-1227.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.