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PDBsum entry 2zn7

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protein ligands links
Hydrolase PDB id
2zn7
Jmol
Contents
Protein chain
297 a.a. *
Ligands
410
Waters ×218
* Residue conservation analysis
PDB id:
2zn7
Name: Hydrolase
Title: Crystal structures of ptp1b-inhibitor complexes
Structure: Tyrosine-protein phosphatase non-receptor type 1. Chain: a. Fragment: catalytic domain, residues 1-299. Synonym: protein-tyrosine phosphatase 1b, ptp-1b. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptp1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.10Å     R-factor:   0.179     R-free:   0.206
Authors: W.Xu,J.Wu
Key ref: Z.K.Wan et al. (2008). Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24. ChemMedChem, 3, 1525-1529. PubMed id: 18798205 DOI: 10.1002/cmdc.200800188
Date:
22-Apr-08     Release date:   07-Oct-08    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P18031  (PTN1_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 1
Seq:
Struc:
435 a.a.
297 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     2 terms  

 

 
    reference    
 
 
DOI no: 10.1002/cmdc.200800188 ChemMedChem 3:1525-1529 (2008)
PubMed id: 18798205  
 
 
Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.
Z.K.Wan, J.Lee, R.Hotchandani, A.Moretto, E.Binnun, D.P.Wilson, S.J.Kirincich, B.C.Follows, M.Ipek, W.Xu, D.Joseph-McCarthy, Y.L.Zhang, M.Tam, D.V.Erbe, J.F.Tobin, W.Li, S.Y.Tam, T.S.Mansour, J.Wu.
 
  ABSTRACT  
 
No abstract given.