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PDBsum entry 2zkx

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protein metals Protein-protein interface(s) links
Oxidoreductase PDB id
2zkx
Jmol
Contents
Protein chains
153 a.a. *
118 a.a. *
Metals
_ZN ×4
CU1 ×4
Waters ×28
* Residue conservation analysis
PDB id:
2zkx
Name: Oxidoreductase
Title: Crystal structure of human cu-zn superoxide dismutase mutant space group i212121
Structure: Superoxide dismutase [cu-zn]. Chain: a, b, c, d. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sod1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.72Å     R-factor:   0.176     R-free:   0.246
Authors: S.Yoshikawa,M.Kukimoto-Niino,K.Ito,L.Chen,Z.Q.Fu,J.Chrzas,B. M.Shirouzu,M.Urushitani,R.Takahashi,S.Yokoyama,Riken Struct Genomics/proteomics Initiative (Rsgi)
Key ref: S.Yoshikawa et al. Crystal structure of human cu-Zn superoxide dismutase mutant g85r in space group i212121. To be published, .
Date:
31-Mar-08     Release date:   24-Mar-09    
Supersedes: 2yqw
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P00441  (SODC_HUMAN) -  Superoxide dismutase [Cu-Zn]
Seq:
Struc:
154 a.a.
153 a.a.*
Protein chain
Pfam   ArchSchema ?
P00441  (SODC_HUMAN) -  Superoxide dismutase [Cu-Zn]
Seq:
Struc:
154 a.a.
118 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D: E.C.1.15.1.1  - Superoxide dismutase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 superoxide + 2 H+ = O2 + H2O2
2 × superoxide
+ 2 × H(+)
= O(2)
+ H(2)O(2)
      Cofactor: Fe cation or Mn(2+) or (Zn(2+) and Cu cation)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   20 terms 
  Biological process     cellular response to potassium ion   66 terms 
  Biochemical function     antioxidant activity     13 terms