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PDBsum entry 2zkw

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protein metals Protein-protein interface(s) links
Oxidoreductase PDB id
2zkw
Jmol
Contents
Protein chain
149 a.a. *
Metals
_ZN ×2
CU1 ×2
Waters ×46
* Residue conservation analysis
PDB id:
2zkw
Name: Oxidoreductase
Title: Crystal structure of human cu-zn superoxide dismutase mutant space group p21
Structure: Superoxide dismutase [cu-zn]. Chain: a, b. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sod1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.90Å     R-factor:   0.193     R-free:   0.252
Authors: S.Yoshikawa,M.Kukimoto-Niino,K.Ito,L.Chen,Z.Q.Fu,J.Chrzas,B. M.Shirouzu,M.Urushitani,R.Takahashi,S.Yokoyama,Riken Struct Genomics/proteomics Initiative (Rsgi)
Key ref: S.Yoshikawa et al. Crystal structure of human cu-Zn superoxide dismutase mutant g85r in space group p21. To be published, .
Date:
31-Mar-08     Release date:   24-Mar-09    
Supersedes: 2yqv
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P00441  (SODC_HUMAN) -  Superoxide dismutase [Cu-Zn]
Seq:
Struc:
154 a.a.
149 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.1.15.1.1  - Superoxide dismutase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 superoxide + 2 H+ = O2 + H2O2
2 × superoxide
+ 2 × H(+)
= O(2)
+ H(2)O(2)
      Cofactor: Fe cation or Mn(2+) or (Zn(2+) and Cu cation)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   16 terms 
  Biological process     reactive oxygen species metabolic process   62 terms 
  Biochemical function     antioxidant activity     12 terms