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PDBsum entry 2zb0

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protein ligands links
Transferase PDB id
2zb0
Jmol
Contents
Protein chain
349 a.a. *
Ligands
GK3
GOL
Waters ×285
* Residue conservation analysis
PDB id:
2zb0
Name: Transferase
Title: Crystal structure of p38 in complex with biphenyl amide inhi
Structure: Mitogen-activated protein kinase 14. Chain: a. Synonym: mitogen-activated protein kinase p38 alpha, map ki alpha, cytokine suppressive anti-inflammatory drug-binding csaid-binding protein, csbp, max-interacting protein 2, map mxi2, sapk2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.10Å     R-factor:   0.174     R-free:   0.212
Authors: D.O.Somers
Key ref: R.M.Angell et al. (2008). Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode. Bioorg Med Chem Lett, 18, 318-323. PubMed id: 18006306 DOI: 10.1016/j.bmcl.2007.10.076
Date:
13-Oct-07     Release date:   15-Jan-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
349 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.bmcl.2007.10.076 Bioorg Med Chem Lett 18:318-323 (2008)
PubMed id: 18006306  
 
 
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
R.M.Angell, P.Bamborough, A.Cleasby, S.G.Cockerill, K.L.Jones, C.J.Mooney, D.O.Somers, A.L.Walker.
 
  ABSTRACT  
 
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.