PDBsum entry: 2z0p

Signaling protein

PDB id: 2z0p

Contents

Protein chains

158 a.a. *

Ligands

4PT ×4

Metals

_ZN ×4

Waters ×68

* Residue conservation analysis

PDB id:

2z0p

Name:

Signaling protein

Title:

Crystal structure of ph domain of bruton's tyrosine kinase

Structure:

Tyrosine-protein kinase btk. Chain: a, b, c, d. Fragment: ph domain. Synonym: bruton tyrosine kinase, agammaglobulinaemia tyrosine kinase, atk, b cell progenitor kinase, bpk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

2.58Å R-factor: 0.242 R-free: 0.300

Authors:

K.Murayama,M.Kato-Murayama,C.Mishima,M.Shirouzu,S.Yokoyama, Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

K.Murayama et al. Crystal structure of ph domain of bruton'S tyrosine kinase. To be published,

Date:

07-May-07 Release date: 13-May-08

Protein chains

Q06187  (BTK_HUMAN) -  Tyrosine-protein kinase BTK

Seq: 659 a.a.

Struc: 158 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - Non-specific protein-tyrosine kinase.
• Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biochemical function: protein binding (1 term)