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PDBsum entry 2z02

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protein ligands Protein-protein interface(s) links
Ligase PDB id
2z02
Jmol
Contents
Protein chains
242 a.a. *
Ligands
ATP ×2
SO4 ×3
CIT
Waters ×299
* Residue conservation analysis
PDB id:
2z02
Name: Ligase
Title: Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase wit atp from methanocaldococcus jannaschii
Structure: Phosphoribosylaminoimidazole-succinocarboxamide synthase. Chain: a, b. Synonym: saicar synthetase. Engineered: yes
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.03Å     R-factor:   0.207     R-free:   0.217
Authors: M.Kanagawa,S.Baba,S.Kuramitsu,S.Yokoyama,G.Kawai,G.Sampei, Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: M.Kanagawa et al. Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase from methanocaldococcus jannaschii. To be published, .
Date:
06-May-07     Release date:   06-Nov-07    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q58987  (PUR7_METJA) -  Phosphoribosylaminoimidazole-succinocarboxamide synthase
Seq:
Struc:
242 a.a.
242 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.3.2.6  - Phosphoribosylaminoimidazolesuccinocarboxamide synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Purine Biosynthesis (late stages)
      Reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate
ATP
Bound ligand (Het Group name = ATP)
corresponds exactly
+ 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
+
L-aspartate
Bound ligand (Het Group name = CIT)
matches with 57.00% similarity
= ADP
+ phosphate
+ (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     purine nucleotide biosynthetic process   2 terms 
  Biochemical function     nucleotide binding     4 terms