PDBsum entry: 2yzl

Ligase

PDB id: 2yzl

Contents

Protein chain

238 a.a. *

Ligands

SO4 ×2

ADP

Waters ×127

* Residue conservation analysis

PDB id:

2yzl

Name:

Ligase

Title:

Crystal structure of phosphoribosylaminoimidazole- succinocarboxamide synthase with adp from methanocaldococcus jannaschii

Structure:

Phosphoribosylaminoimidazole-succinocarboxamide synthase. Chain: a. Synonym: saicar synthetase. Engineered: yes

Source:

Methanocaldococcus jannaschii. Organism_taxid: 2190. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.20Å R-factor: 0.228 R-free: 0.248

Authors:

M.Kanagawa,S.Baba,K.Fukui,S.Kuramitsu,S.Yokoyama,G.Kawai, G.Sampei,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

M.Kanagawa et al. Crystal structure of phosphoribosylaminoimidazole-Succinocarboxamide synthase with adp from methanocaldococcus jannaschii. To be published,

Date:

06-May-07 Release date: 06-Nov-07

Protein chain

Q58987  (PUR7_METJA) -  Phosphoribosylaminoimidazole-succinocarboxamide synthase

Seq: 242 a.a.

Struc: 238 a.a.

Enzyme reactions

• Enzyme class: E.C.6.3.2.6 - Phosphoribosylaminoimidazolesuccinocarboxamide synthase.
• Pathway: Purine Biosynthesis (late stages)
• Reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP (Bound ligand (Het Group name = ADP) corresponds exactly) + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: purine nucleotide biosynthetic process (1 term)
• Biochemical function: catalytic activity (5 terms)