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Contents |
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* Residue conservation analysis
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PDB id:
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Ligase
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Title:
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Crystal structure of gar synthetase from aquifex aeolicus
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Structure:
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Phosphoribosylamine--glycine ligase. Chain: a, b. Synonym: gars, glycinamide ribonucleotide synthetase, phosphoribosylglycinamide synthetase. Engineered: yes
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Source:
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Aquifex aeolicus. Organism_taxid: 63363. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.40Å
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R-factor:
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0.225
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R-free:
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0.249
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Authors:
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S.Baba,M.Kanagawa,S.Kuramitsu,S.Yokoyama,G.Kawai,G.Sampei,Ri Structural Genomics/proteomics Initiative (Rsgi)
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Key ref:
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G.Sampei
et al.
(2010).
Crystal structures of glycinamide ribonucleotide synthetase, PurD, from thermophilic eubacteria.
J Biochem,
148,
429-438.
PubMed id:
Ref:
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Date:
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27-Apr-07
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Release date:
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30-Oct-07
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PROCHECK
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Headers
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References
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O66949
(PUR2_AQUAE) -
Phosphoribosylamine--glycine ligase
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Seq:
Struc:
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424 a.a.
423 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.6.3.4.13
- Phosphoribosylamine--glycine ligase.
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Pathway:
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Purine Biosynthesis (early stages)
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Reaction:
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ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1- (5-phospho-D-ribosyl)glycinamide
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ATP
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+
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5-phospho-D-ribosylamine
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+
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glycine
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=
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ADP
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+
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phosphate
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+
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N(1)- (5-phospho-D-ribosyl)glycinamide
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Gene Ontology (GO) functional annotation
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Biological process
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purine base biosynthetic process
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2 terms
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Biochemical function
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catalytic activity
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6 terms
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J Biochem
148:429-438
(2010)
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PubMed id:
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Crystal structures of glycinamide ribonucleotide synthetase, PurD, from thermophilic eubacteria.
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G.Sampei,
S.Baba,
M.Kanagawa,
H.Yanai,
T.Ishii,
H.Kawai,
Y.Fukai,
A.Ebihara,
N.Nakagawa,
G.Kawai.
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ABSTRACT
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Links
