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PDBsum entry 2yu7

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protein Protein-protein interface(s) links
Signaling protein PDB id
2yu7
Jmol
Contents
Protein chains
118 a.a. *
15 a.a. *
* Residue conservation analysis
PDB id:
2yu7
Name: Signaling protein
Title: Solution structure of the shp-1 c-terminal sh2 domain complexed with a tyrosine-phosphorylated peptide from nkg2a
Structure: Tyrosine-protein phosphatase non-receptor type 6. Chain: a. Fragment: sh2 domain. Synonym: sh2-domain phosphatase 1, protein-tyrosine phosphatase 1c, ptp-1c, hematopoietic cell protein- tyrosine phosphatase, sh-ptp1, protein-tyrosine phosphatase shp-1. Engineered: yes. Natural killer group 2a.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: shp1. Other_details: cell-free protein synthesis. Synthetic: yes. Other_details: the human nkg2a phosphorylated peptide is chemicaly synthesized.
NMR struc: 20 models
Authors: T.Kasai,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: T.Kasai et al. Solution structure of the shp-1 c-Terminal sh2 domain complexed with a tyrosine-Phosphorylated peptide from nkg2a. To be published, .
Date:
05-Apr-07     Release date:   15-Apr-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P29350  (PTN6_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 6
Seq:
Struc:
 
Seq:
Struc:
595 a.a.
118 a.a.*
Protein chain
Pfam   ArchSchema ?
P26715  (NKG2A_HUMAN) -  NKG2-A/NKG2-B type II integral membrane protein
Seq:
Struc:
233 a.a.
15 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 12 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain A: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site