PDBsum entry: 2ys5

Signaling protein

PDB-id: 2ys5

Contents

Description

Header details

Header records

References

PROCHECK

Protein chains

146 a.a. *

19 a.a. *

* Residue conservation analysis

Tools

Clefts Calculation

PDB id:

2ys5

Name:

Signaling protein

Title:

Solution structure of the complex of the ptb domain of snt- 2 and 19-residue peptide (aa 1571-1589) of halk

Structure:

Fibroblast growth factor receptor substrate 3. Chain: a. Fragment: ptb domain. Synonym: fgfr substrate 3, suc1-associated neurotrophic factor target 2, snt-2, fgfr-signaling adaptor snt2. Engineered: yes. Alk tyrosine kinase receptor. Chain: b. Fragment: residues in database 1571-1589.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: frs3. Other_details: cell-free protein synthesis. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence is taken from homo sapiens.

UniProt:

Chain A: O43559 (FRS3_HUMAN)

Seq:
Struc:
	Seq:	492 a.a.
	Struc:	146 a.a.*

Chain B: Q9UM73 (ALK_HUMAN)

Seq:

Struc:

Seq:

Struc:

Seq:

Struc:

Seq:

Struc:

Seq:

Struc:

Seq:

Struc:

Seq:

1620 a.a.

Struc:

19 a.a.

Key:

PfamA domain

Secondary structure

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme class:

Chain B: E.C.2.7.10.1   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Reaction:

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Resolution:

not givenÅ

NMR structure:

20 models

Authors:

H.Li,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

h.li et al. solution structure of the complex of the ptb domain of snt-2 and 19-residue peptide (aa 1571-1589) of halk. TO BE PUBLISHED, .

Date:

03-Apr-07

Release date:

08-Apr-08

Related entries:

Hsi002009654.1 related db: targetdb

Quick_links

Procheck

Clefts

Surface