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PDBsum entry 2yis

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protein ligands links
Transferase PDB id
2yis
Jmol
Contents
Protein chain
326 a.a.
Ligands
YIS
I46
Waters ×247
PDB id:
2yis
Name: Transferase
Title: Triazolopyridine inhibitors of p38 kinase.
Structure: Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti-inflammatory drug-binding protein, csaid-binding prot csbp, map kinase mxi2, max-interacting protein 2, p38 kina mitogen-activated protein kinase p38 alpha, map kinase p38 sapk2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.00Å     R-factor:   0.216     R-free:   0.254
Authors: D.S.Millan,M.Anderson,R.Bazin,M.E.Bunnage,J.L.Burrows,K.J.Bu P.G.Dodd,T.J.Evans,D.A.Fairman,S.J.Hughes,S.L.Irving,I.C.Ki A.Lemaitre,R.A.Lewthwaite,A.Mahnke,J.P.Mathais,J.Philip,C.P R.T.Smith,M.H.Stefaniack,M.Yeadon
Key ref: D.S.Millan et al. (2011). Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. J Med Chem, 54, 7797-7814. PubMed id: 21888439 DOI: 10.1021/jm200677b
Date:
16-May-11     Release date:   30-Nov-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
326 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms  

 

 
    reference    
 
 
DOI no: 10.1021/jm200677b J Med Chem 54:7797-7814 (2011)
PubMed id: 21888439  
 
 
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
D.S.Millan, M.E.Bunnage, J.L.Burrows, K.J.Butcher, P.G.Dodd, T.J.Evans, D.A.Fairman, S.J.Hughes, I.C.Kilty, A.Lemaitre, R.A.Lewthwaite, A.Mahnke, J.P.Mathias, J.Philip, R.T.Smith, M.H.Stefaniak, M.Yeadon, C.Phillips.
 
  ABSTRACT  
 
No abstract given.