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PDBsum entry 2yin

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protein Protein-protein interface(s) links
Apoptosis PDB id
2yin
Jmol
Contents
Protein chains
411 a.a.
180 a.a.
Waters ×91
PDB id:
2yin
Name: Apoptosis
Title: Structure of the complex between dock2 and rac1.
Structure: Dedicator of cytokinesis protein 2. Chain: a, b. Fragment: dhr2 domain, residues 1192-1622. Synonym: dock2. Engineered: yes. Other_details: cis peptide between 1475 and 1476 residues o a and b.. Ras-related c3 botulinum toxin substrate 1. Chain: c, d.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.70Å     R-factor:   0.205     R-free:   0.254
Authors: K.A.Kulkarni,J.Yang,Z.Zhang,D.Barford
Key ref: K.Kulkarni et al. (2011). Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors. J Biol Chem, 286, 25341-25351. PubMed id: 21613211 DOI: 10.1074/jbc.M111.236455
Date:
16-May-11     Release date:   25-May-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q92608  (DOCK2_HUMAN) -  Dedicator of cytokinesis protein 2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1830 a.a.
411 a.a.
Protein chains
Pfam   ArchSchema ?
P63000  (RAC1_HUMAN) -  Ras-related C3 botulinum toxin substrate 1
Seq:
Struc:
192 a.a.
180 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     intracellular   18 terms 
  Biological process     epithelial cell morphogenesis   68 terms 
  Biochemical function     nucleotide binding     11 terms  

 

 
DOI no: 10.1074/jbc.M111.236455 J Biol Chem 286:25341-25351 (2011)
PubMed id: 21613211  
 
 
Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
K.Kulkarni, J.Yang, Z.Zhang, D.Barford.
 
  ABSTRACT  
 
No abstract given.