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PDBsum entry 2yd8

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protein ligands links
Hydrolase PDB id
2yd8
Jmol
Contents
Protein chain
198 a.a.
Ligands
SCR
Waters ×96
PDB id:
2yd8
Name: Hydrolase
Title: Crystal structure of the n-terminal ig1-2 module of human receptor protein tyrosine phosphatase lar in complex with sucrose octasulphate
Structure: Receptor-type tyrosine-protein phosphatase f. Chain: a. Fragment: ig1-2, residues 29-231. Synonym: leukocyte common antigen related, lar, receptor pr tyrosine phosphatase lar. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
Resolution:
2.05Å     R-factor:   0.196     R-free:   0.226
Authors: C.H.Coles,Y.Shen,A.P.Tenney,C.Siebold,G.C.Sutton,W.Lu,J.T.Ga E.Y.Jones,J.G.Flanagan,A.R.Aricescu
Key ref: C.H.Coles et al. (2011). Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension. Science, 332, 484-488. PubMed id: 21454754
Date:
18-Mar-11     Release date:   13-Apr-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P10586  (PTPRF_HUMAN) -  Receptor-type tyrosine-protein phosphatase F
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1907 a.a.
198 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
Science 332:484-488 (2011)
PubMed id: 21454754  
 
 
Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.
C.H.Coles, Y.Shen, A.P.Tenney, C.Siebold, G.C.Sutton, W.Lu, J.T.Gallagher, E.Y.Jones, J.G.Flanagan, A.R.Aricescu.
 
  ABSTRACT  
 
No abstract given.