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PDBsum entry 2y6e

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protein ligands metals Protein-protein interface(s) links
Hydrolase PDB id
2y6e
Jmol
Contents
Protein chains
337 a.a.
319 a.a.
Ligands
SO4 ×2
Metals
_ZN ×6
Waters ×1249
PDB id:
2y6e
Name: Hydrolase
Title: Ubiquitin specific protease 4 is inhibited by its ubiquitin- like domain
Structure: Ubiquitin carboxyl-terminal hydrolase 4. Chain: a, b, c, d, e, f. Fragment: catalytic domain, residues 296-490,765-932. Synonym: ubiquitin-specific-processing protease 4, deubiqui enzyme 4, ubiquitin thiolesterase 4, ubiquitous nuclear pr homolog, usp4. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.40Å     R-factor:   0.179     R-free:   0.210
Authors: M.P.A.Luna-Vargas,A.C.Faesen,W.J.Van Dijk,M.Rape,A.Fish,T.K.
Key ref: M.P.Luna-Vargas et al. (2011). Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain. EMBO Rep, 12, 365-372. PubMed id: 21415856
Date:
20-Jan-11     Release date:   06-Apr-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q13107  (UBP4_HUMAN) -  Ubiquitin carboxyl-terminal hydrolase 4
Seq:
Struc:
 
Seq:
Struc:
963 a.a.
337 a.a.*
Protein chains
Pfam   ArchSchema ?
Q13107  (UBP4_HUMAN) -  Ubiquitin carboxyl-terminal hydrolase 4
Seq:
Struc:
 
Seq:
Struc:
963 a.a.
319 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D, E, F: E.C.3.4.19.12  - Ubiquitinyl hydrolase 1.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Thiol-dependent hydrolysis of ester, thiolester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein deubiquitination   2 terms 
  Biochemical function     ?     1 term  

 

 
EMBO Rep 12:365-372 (2011)
PubMed id: 21415856  
 
 
Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.
M.P.Luna-Vargas, A.C.Faesen, W.J.van Dijk, M.Rape, A.Fish, T.K.Sixma.
 
  ABSTRACT  
 
No abstract given.