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PDBsum entry 2y2v

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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
2y2v
Jmol
Contents
Protein chains
531 a.a.
Ligands
NAG ×3
PEG ×3
ME2 ×2
P15
ETX
Waters ×729
PDB id:
2y2v
Name: Hydrolase
Title: Nonaged form of mouse acetylcholinesterase inhibited by sarin-update
Structure: Acetylcholinesterase. Chain: a, b. Fragment: catalytic domain, residues 32-574. Synonym: ache. Engineered: yes. Other_details: catalytic ser203 phosphonylated by sarin
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f
Resolution:
2.45Å     R-factor:   0.185     R-free:   0.224
Authors: C.Akfur,E.Artursson,F.Ekstrom
Key ref: C.Akfur et al. Methylphosphonate adducts of acetylcholinesterase investigated by time correlated single photon countin X-Ray crystallography. To be published, .
Date:
16-Dec-10     Release date:   30-Nov-11    
Supersedes: 2jgg
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P21836  (ACES_MOUSE) -  Acetylcholinesterase
Seq:
Struc:
 
Seq:
Struc:
614 a.a.
531 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.1.1.7  - Acetylcholinesterase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Acetylcholine + H2O = choline + acetate
Acetylcholine
Bound ligand (Het Group name = NAG)
matches with 41.18% similarity
+ H(2)O
= choline
+
acetate
Bound ligand (Het Group name = ETX)
matches with 42.86% similarity
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   12 terms 
  Biological process     cell adhesion   9 terms 
  Biochemical function     carboxylic ester hydrolase activity     10 terms