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PDBsum entry 2y2u

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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
2y2u
Jmol
Contents
Protein chains
537 a.a.
Ligands
NAG ×3
PEG ×5
P33
Waters ×357
PDB id:
2y2u
Name: Hydrolase
Title: Nonaged form of mouse acetylcholinesterase inhibited by vx-u
Structure: Acetylcholinesterase. Chain: a, b. Fragment: catalytic domain, residues 32-574. Synonym: ache. Engineered: yes. Other_details: catalytic ser203 phosphonylated by vx
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f
Resolution:
2.60Å     R-factor:   0.188     R-free:   0.237
Authors: C.Akfur,E.Artursson,F.Ekstrom
Key ref: C.Akfur et al. Methylphosphonate adducts of acetylcholinesterase investigated by time correlated single photon countin X-Ray crystallography. To be published, .
Date:
16-Dec-10     Release date:   30-Nov-11    
Supersedes: 2jgh
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P21836  (ACES_MOUSE) -  Acetylcholinesterase
Seq:
Struc:
 
Seq:
Struc:
614 a.a.
537 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.1.7  - Acetylcholinesterase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Acetylcholine + H2O = choline + acetate
Acetylcholine
Bound ligand (Het Group name = NAG)
matches with 41.18% similarity
+ H(2)O
= choline
+
acetate
Bound ligand (Het Group name = PEG)
matches with 50.00% similarity
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   17 terms 
  Biological process     synapse assembly   13 terms 
  Biochemical function     carboxylic ester hydrolase activity     9 terms