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PDBsum entry 2xue
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Oxidoreductase
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PDB id
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2xue
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Crystal structure of jmjd3
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Structure:
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Lysine-specific demethylase 6b. Chain: a, b. Fragment: catalytic domain, residues 1138-1640. Synonym: jmjd3, jmjc domain-containing protein 3, jumonji domain- containing protein 3, lysine demethylase 6b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Resolution:
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2.00Å
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R-factor:
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0.181
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R-free:
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0.216
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Authors:
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C.Chung,P.Rowland,J.Mosley,P.J.Thomas
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Key ref:
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L.Kruidenier
et al.
(2012).
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Nature,
488,
404-408.
PubMed id:
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Date:
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19-Oct-10
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Release date:
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28-Dec-11
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PROCHECK
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Headers
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References
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O15054
(KDM6B_HUMAN) -
Lysine-specific demethylase 6B from Homo sapiens
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Seq:
Struc:
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1643 a.a.
427 a.a.
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Key: |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.1.14.11.68
- [histone H3]-trimethyl-L-lysine(27) demethylase.
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Reaction:
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N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 2 2-oxoglutarate + 2 O2 = N6-methyl-L-lysyl27-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2
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N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3]
Bound ligand (Het Group name = )
corresponds exactly
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+
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2
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2-oxoglutarate
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+
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2
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O2
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=
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N(6)-methyl-L-lysyl(27)-[histone H3]
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+
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2
×
formaldehyde
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+
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2
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succinate
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+
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2
×
CO2
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Nature
488:404-408
(2012)
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PubMed id:
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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
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L.Kruidenier,
C.W.Chung,
Z.Cheng,
J.Liddle,
K.Che,
G.Joberty,
M.Bantscheff,
C.Bountra,
A.Bridges,
H.Diallo,
D.Eberhard,
S.Hutchinson,
E.Jones,
R.Katso,
M.Leveridge,
P.K.Mander,
J.Mosley,
C.Ramirez-Molina,
P.Rowland,
C.J.Schofield,
R.J.Sheppard,
J.E.Smith,
C.Swales,
R.Tanner,
P.Thomas,
A.Tumber,
G.Drewes,
U.Oppermann,
D.J.Patel,
K.Lee,
D.M.Wilson.
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ABSTRACT
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