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PDBsum entry 2xoi

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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
2xoi
Jmol
Contents
Protein chains
123 a.a. *
Ligands
SFB ×2
Waters ×283
* Residue conservation analysis
PDB id:
2xoi
Name: Hydrolase
Title: Functional and structural analyses of n-acylsulfonamide- linked dinucleoside inhibitors of ribonuclease a
Structure: Ribonuclease pancreatic. Chain: a, b. Synonym: rnase 1, rnase a, bovine pancreatic ribonuclease a ec: 3.1.27.5
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Other_details: supplier is sigma
Resolution:
1.72Å     R-factor:   0.216     R-free:   0.245
Authors: N.Thiyagarajan,B.D.Smith,R.T.Raines,K.R.Acharya
Key ref: N.Thiyagarajan et al. (2011). Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A. FEBS J, 278, 541-549. PubMed id: 21205197
Date:
17-Aug-10     Release date:   19-Jan-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P61823  (RNAS1_BOVIN) -  Ribonuclease pancreatic
Seq:
Struc:
150 a.a.
123 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.27.5  - Pancreatic ribonuclease.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   1 term 
  Biological process     metabolic process   3 terms 
  Biochemical function     nucleic acid binding     7 terms  

 

 
FEBS J 278:541-549 (2011)
PubMed id: 21205197  
 
 
Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A.
N.Thiyagarajan, B.D.Smith, R.T.Raines, K.R.Acharya.
 
  ABSTRACT  
 
No abstract given.